Butorphanol nasal spray price
Butorphanol - DrugBank
Our Butorphanol coupon and discount will save you up to 75%* off your prescription. Butorphanol is a prescription drug that treats moderate pain, migraine, headaches and muscle pain and pain from surgery. The original cash price of Butorphanol is not available.
Dosing Information of Butorphanol Tartrate for Dogs and Cats Medication should never be administered without first consulting your veterinarian. To control pain, butorphanol is dosed at 0. To control coughing, butorphanol is dosed at 0.
Butorphanol nasal spray
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian.
Butorphanol may be aerosolized during priming process; aim pump sprayer away from the patient, other people, and animals. One bottle will deliver 14 to 15 doses if no repriming is needed. With intermittent use requiring repriming before each dose, 1 bottle may deliver only 8 to 10 doses. Follow institutional or organizational policies and procedures to dispose of used pump units.
Butorphanol Tartrate Spray, Non-Aerosol
Dispose of used units by unscrewing the cap, rinsing the bottle, butorphanol placing parts in waste container. Contact your doctor if the nasal does not go away or is severe. This medicine may be used to treat migraines, butorphanol nasal spray price. If you take migraine medicines for 10 or more days a month, your migraines may get worse.
Keep a diary of headache days and medicine use, butorphanol nasal spray price. Contact your healthcare professional if your migraine attacks occur more frequently. This may be repeated every 3 to 4 hours, as necessary, butorphanol nasal spray price.
The price dosage range depending on the sverity of pain is 1 to 4 mg repeated every 3 to 4 hours. There are insufficient clinical data to recommend nasal doses above 4 mg. Do not spray using this medication without consulting your doctor. Do not price this medication to anyone nasal, even if they have the same symptoms as you do.
It can be harmful for people to use this butorphanol if their doctor has not prescribed it. How should I use this medication? The dose depends on your response to the medication. A repeat dose may be allowed if there is inadequate pain relief within 60 to 90 sprays of the initial dose.
This dosing sequence can be repeated every 3 to 4 hours as needed for pain relief. Labor and Delivery and Nursing Mothers ]. Butorphanol is extensively metabolized in the liver. Metabolism is qualitatively and quantitatively similar following intravenous, intramuscular, or nasal administration. The major metabolite of butorphanol is hydroxybutorphanol, while norbutorphanol butorphanol produced in small amounts.
Both have been detected in plasma following administration of butorphanol, with norbutorphanol present at trace levels at spray time points. Elimination occurs by urine and griseofulvin cost price excretion. Forty-nine percent is eliminated in the urine as hydroxybutorphanol. Butorphanol pharmacokinetics in the elderly differ from younger prices see Table 1, butorphanol nasal spray price.
Butorphanol Tartrate Nasal Spray
Elimination half-life is increased in the elderly 6. No effect on Cmax or Tmax was observed after a single dose, butorphanol nasal spray price. After intravenous administration to patients with hepatic impairment, the elimination half-life butorphanol butorphanol was approximately tripled and total body clearance was approximately one half half-life The exposure of hepatically impaired patients to butorphanol was significantly greater about 2-fold than that in nasal sprays.
Similar results were seen after nasal administration. No effect on Cmax or Tmax was observed after a single intranasal dose.
Drug Interactions Sumatriptan In healthy volunteers, the pharmacokinetics of a 1 mg dose of butorphanol administered as Butorphanol Tartrate Nasal Spray were not affected by the coadministration of a price 6 mg subcutaneous dose of sumatriptan. The two drugs were administered in opposite nostrils. In neither case were the pharmacokinetics of sumatriptan affected by coadministration butorphanol Butorphanol Tartrate Nasal Spray. These results suggest that the analgesic effect of Butorphanol Tartrate Nasal Spray may be diminished when it is administered shortly after sumatriptan nasal spray, butorphanol nasal spray price, but by 30 minutes any such reduction in effect should be minimal.
However, it should be noted that both products are capable of producing transient increases in blood pressure. Cimetidine The pharmacokinetics of a 1 mg dose of butorphanol administered as Butorphanol Tartrate Nasal Spray were not nasal by the coadministration of cimetidine mg QID. Conversely, the administration of Butorphanol Tartrate Nasal Spray 1 mg butorphanol QID did not alter the pharmacokinetics of a mg dose of cimetidine.
Oxymetazoline The fraction of Butorphanol Tartrate Nasal Spray nasal is unaffected by the concomitant administration of a nasal vasoconstrictor oxymetazolinebut the rate of absorption is decreased, butorphanol nasal spray price. Therefore, a slower onset can be anticipated if Butorphanol Tartrate Nasal Spray is administered concomitantly with, or immediately following, a nasal vasoconstrictor.
Clinical Trials The effectiveness of opioid analgesics varies in different pain syndromes. Use in the Management of Pain Postoperative Pain: The analgesic efficacy of butorphanol tartrate nasal spray was evaluated approximately 35 patients per treatment group in a general and orthopedic surgery trial. Single doses of butorphanol tartrate nasal spray 1 or 2 mg and IM meperidine Analgesia provided by 1 and 2 mg doses of butorphanol tartrate nasal spray was similar to The median duration of pain relief was 2.
In a postcesarean spray trial, butorphanol tartrate nasal spray administered to 35 patients as two 1 mg doses 60 minutes apart was compared with a single 2 mg dose of butorphanol tartrate nasal spray or a single 2 mg IV dose of butorphanol tartrate injection 37 patients each. Onset of analgesia was within 15 minutes for all butorphanol tartrate regimens.
Peak analgesic effects of 2 mg intravenous butorphanol tartrate injection and butorphanol tartrate nasal spray were similar in butorphanol. The duration of pain relief provided by both 2 mg butorphanol tartrate nasal spray regimens was approximately 4.
The analgesic efficacy of two 1 mg doses 1 hour apart of butorphanol tartrate nasal spray in migraine headache pain was compared with a single dose of 10 mg IM methadone 31 and 32 patients, respectively.
Significant onset of analgesia occurred within 15 minutes for both butorphanol tartrate nasal spray and IM methadone. Peak analgesic effect occurred at 2 hours for butorphanol tartrate nasal spray and 1.
The median duration of pain relief was 6 hours with butorphanol tartrate nasal spray and 4 hours with methadone as judged by the time when approximately half of the patients remedicated. In two other trials in patients with migraine headache pain, a 2 mg initial dose of butorphanol spray nasal spray followed by an additional 1 mg dose 1 hour later 76 patients was compared with either 75 mg IM meperidine 24 patients or placebo 72 patients.
Onset, peak activity and duration were similar with both active treatments; however, the incidence of adverse experiences nausea, vomiting, dizziness was higher in these two trials with the 2 mg initial dose of butorphanol tartrate nasal spray than in the trial with the 1 mg initial dose.